Noopept, Adamax and Bromantane: chemical profiles at a glance

Three compounds, three very different molecules: a dipeptide ester, a modified heptapeptide and an adamantane amine. This page collects the chemistry you need when you plan an experiment — identifiers, formulas, molecular weights and how many micromoles are in one pre-weighed unit — in one place.

Side-by-side comparison

Noopept

Noopept is a synthetic N-acylprolyl-containing dipeptide ethyl ester: a phenylacetyl group on the nitrogen of L-proline, coupled to glycine, with the C-terminus protected as an ethyl ester. It is also known by the international non-proprietary name omberacetam and the code GVS-111.

With a molecular weight of 318.37 g/mol, it is a small, neutral molecule compared with the peptides it is often discussed alongside. Every lot is assayed by HPLC and identity-confirmed before release.

Adamax

Adamax is a synthetic analogue of the heptapeptide semax, carrying modified N- and C-termini. At 1032.23 g/mol it is by far the largest of the three molecules, and its formula contains a sulfur atom — the side chain of a methionine residue.

That matters in the lab: methionine is one of the residues most prone to oxidation, which is one reason peptide material should be kept dry, sealed and away from light. No CAS number has been assigned to Adamax so far, so the name, formula and lot number are the identifiers to record. Peptide content and purity are determined by HPLC; identity is confirmed by mass spectrometry.

Bromantane

Bromantane (ladasten) is an adamantane derivative: the rigid, cage-shaped adamantane skeleton carries a 4-bromophenylamino group at its 2-position. The bulky, lipophilic cage is characteristic of the whole adamantane family.

Researchers working in sport-science contexts should note that bromantane appears on the World Anti-Doping Agency (WADA) prohibited list.

Molar quantities per unit

For solution work it is usually the number of moles, not milligrams, that counts. Dividing the strength of one unit by the molecular weight gives:

Remember that HPLC purity is an area-percent figure (see how to read a certificate of analysis); for exact concentration work, correct the mass for the purity of the lot you are using.